Oxycodone → Morphine Oxycodone

HRID 1926555Notes

Reaction equation

[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]>>[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]

Participants

Reactant 2

HCID 5284603Oxycodone4×

HCID 5288826Morphine4×

Product 1

HCID 9830161Morphine Oxycodone

Procedure

Objective The main objective was to compare the ventilatory responses to hypoxia and hypercarbia following one hour intravenous infusions of (1) morphine 15 mg, or (2) oxycodone 15 mg, or (3) morphine 10 mg+oxycodone 5 mg, or (4) oxycodone 10 mg+morphine 5 mg, or (5) morphine 7.5 mg+oxycodone 7.5 mg. Each infusion was administered over 1 h and was designated by its respective composition as M15, M10—05, M7.5—07.5, M5—010 or 015.

Workup

waitEach infusion was administered over 1 h

Sources & evidence

ORD record: ord-4334512900fe425dbf81f123a85d5a69
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08182837B2

Reaction notes

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