HRID1926555

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314

HCID5284603

Oxycodone

C18H21NO4

4 次

结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5

HCID5288826

Morphine

C17H19NO3

4 次

PRODUCTS

生成物

结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314

HCID9830161

未命名化合物

PROCEDURE

实验过程

Objective The main objective was to compare the ventilatory responses to hypoxia and hypercarbia following one hour intravenous infusions of (1) morphine 15 mg, or (2) oxycodone 15 mg, or (3) morphine 10 mg+oxycodone 5 mg, or (4) oxycodone 10 mg+morphine 5 mg, or (5) morphine 7.5 mg+oxycodone 7.5 mg. Each infusion was administered over 1 h and was designated by its respective composition as M15, M10—05, M7.5—07.5, M5—010 or 015.

WORKUP

后处理

waitEach infusion was administered over 1 h

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4334512900fe425dbf81f123a85d5a69
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08182837B2
来源说明: uspto-grants-2012_05

反应 SMILES

[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]>>[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]