Mci-186 → HCID 178433859, compound

HRID 1926571Notes

Reaction equation

HRID 1926571 reaction equation
[CH3:1][C@H:2]1[CH2:7][C@H:6]([C:8]([OH:10])=[O:9])[N:5]([C:11]([C@@H:13]([NH:21][S:22]([C:25]2[CH:26]=[CH:27][CH:28]=[C:29]3[CH2:34][CH:33]([CH3:35])[CH2:32][NH:31][C:30]=23)(=[O:24])=[O:23])[CH2:14][CH2:15][CH2:16][NH:17][C:18]([NH2:20])=[NH:19])=[O:12])[CH2:4][CH2:3]1.[CH3:36][C:37]1[CH2:42][C:40](=[O:41])[N:39]([C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=2)[N:38]=1>>[CH3:1][C@H:2]1[CH2:7][C@H:6]([C:8]([OH:10])=[O:9])[N:5]([C:11]([C@@H:13]([NH:21][S:22]([C:25]2[CH:26]=[CH:27][CH:28]=[C:29]3[CH2:34][CH:33]([CH3:35])[CH2:32][NH:31][C:30]=23)(=[O:23])=[O:24])[CH2:14][CH2:15][CH2:16][NH:17][C:18]([NH2:20])=[NH:19])=[O:12])[CH2:4][CH2:3]1.[CH3:36][C:37]1[CH2:42][C:40](=[O:41])[N:39]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[N:38]=1

Participants

3

Reactant 2

HCID 4021Mci-186HCID 178429896HCID 178429896, compound2×

Product 1

HCID 178433859HCID 178433859, compound

Procedure

For the first two days, 60 mg/120 ml of argatroban was diluted with an adequate amount of a transfusion fluid and the resulting solution was intravenously infused constantly over 24 hours. For the following 5 days, 10 mg/20 ml of argatroban was diluted with an adequate amount of a transfusion fluid and the resulting solution was intravenously infused twice daily, that is, in the morning and evening, each over 3 hours; and at the same time, 30 mg/20 ml of edaravone was diluted with an adequate amount of physiological saline and the resulting solution was intravenously infused for 2 weeks twice daily, that is, in the morning and evening, each over 30 minutes.

Workup

  1. waiteach over 3 hours
  2. waitthe resulting solution was intravenously infused for 2 weeks
  3. waiteach over 30 minutes

Sources & evidence

ORD record
ord-52f2402c0cf64f7fb44317f0942eaf82
Source dataset
uspto-grants-2012_05
Patent number
US08183206B2

Reaction notes

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