Sodium Carbonate → Sodium Carbonate

HRID 1926573Notes

Reaction equation

HRID 1926573 reaction equation
[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH2:12]2)=[C:8]([C:21]([OH:23])=[O:22])[N:7]2[C@H:3]1[C@@H:4]([C@H:24]([OH:26])[CH3:25])[C:5]2=[O:6].O.O.O.[C:30](=[O:33])([O-:32])[O-:31].[Na+:34].[Na+]>O>[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([N:18]([CH3:19])[CH3:20])=[O:17])[CH2:12]2)=[C:8]([C:21]([OH:23])=[O:22])[N:7]2[C@H:3]1[C@@H:4]([C@H:24]([OH:26])[CH3:25])[C:5]2=[O:6].[C:30](=[O:31])([O-:33])[O-:32].[Na+:34].[Na+:34]

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 441129Meropenem Trihydrate

Product 2

HCID 10340Sodium CarbonateHCID 441130Meropenem

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The following formulations were prepared by mixing the ingredients shown below in a refrigerated vessel (2-8° C.). The meropenem trihydrate was received as bulk raw material (meropenem bulk blend) that already contained added sodium carbonate (Na2CO3). Dissolution of 1.42 g of the blended material in 50 mL of distilled water resulted in a final concentration of 20 mg/mL meropenem and 4.16 mg/mL sodium carbonate.

Workup

  1. customThe following formulations were prepared
  2. additionby mixing the ingredients
  3. customshown below in a refrigerated vessel
  4. custom(2-8° C.)

Sources & evidence

ORD record
ord-35e204f136c1464f9b17aeae5fd5126f
Source dataset
uspto-grants-2012_05
Patent number
US08183233B2

Reaction notes

Loading…