Formaldehyde → HCID 49784756, compound

HRID 1926583Notes

Reaction equation

HRID 1926583 reaction equation
[ClH:1].[N:2]1([C:9]2[CH:10]=[C:11]([NH:16][S:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH:27]([F:29])[F:28])(=[O:19])=[O:18])[CH:12]=[CH:13][C:14]=2[CH3:15])[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:30]=O>[BH4-].[Na+].C(#N)C>[ClH:1].[F:28][CH:27]([F:29])[O:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[S:17]([NH:16][C:11]1[CH:12]=[CH:13][C:14]([CH3:15])=[C:9]([N:2]2[CH2:8][CH2:7][CH2:6][N:5]([CH3:30])[CH2:4][CH2:3]2)[CH:10]=1)(=[O:19])=[O:18]

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 49784750HCID 49784750, compound

Product 1

HCID 49784756HCID 49784756, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 4311764Sodium borohydrideSolvent

Procedure

The title compound was prepared from the title compound of Example 2 under reductive amination conditions employing an aqueous solution of formaldehyde and sodium borohydride in acetonitrile as solvent.

Sources & evidence

ORD record
ord-72f268a21d6f43699711fe55b169a07c
Source dataset
uspto-grants-2012_05
Patent number
US08183237B2

Reaction notes

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