HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → 4-[(4-Methylpiperazin-1-yl)methyl]-n-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl} benzamide methanesulfonic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl}benzamide | HCID 69227800 | — |
| Product | 4-[(4-Methylpiperazin-1-yl)methyl]-n-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl} benzamide methanesulfonic acid salt | HCID 87744083 | 92.1% |
Reaction Steps
To a flask was added 4-[(4-methylpiperazin-1-yl) methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl}benzamide (2.0 g), methanesulfonic acid (0.40 g) and purified water (100 mL). After the solution was clear, the reaction mixture was filtrated and the filtrate was freeze-dried to give 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl} benzamide methanesulfonic acid salt (2.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183242B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-20dfd9a39f134cd1929600576611a31d |
| Source note | uspto-grants-2012_05 |