Potassium Carbonate → HCID 57502416, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 4-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}piperazine-1-carboxylate (0.077 g, 0.13 mmol) in MeOH (1.3 ml) was added potassium carbonate (0.053 g, 0.34 mmol). The reaction mixture was stirred at 50° C. for 1 hour, then at room temperature for 16 hours. The reaction mixture was diluted with MeOH (10 mL) and DCM (10 mL), silica gel was added, and concentrated to a crude residue. The crude residue was purified by silica gel chromatography (EtOAc/Hexanes gradient, followed by MeOH/DCM gradient) to afford tert-butyl 4-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}piperazine-1-carboxylate as a white solid. LRMS calculated for C24H28N8O2 [M+H]+, 461.2; found 461.2.

Provenance & Evidence