Hydrochloric Acid → HCID 25242487, compound

Participants

Reaction Steps

tert-butyl 4-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}piperazine-1-carboxylate (0.047 g, 0.10 mmol) was suspended in dioxane (1.0 ml). 4M HCl in dioxane (1.0 ml) was added, and the reaction mixture was stirred at room temperature for 45 min. The reaction mixture was filtered to afford 5-(1-methyl-1H-pyrazol-4-yl)-3-(6-piperazin-1-ylpyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridine as an orange/yellow solid (hydrochloride salt). 1H NMR (600 MHz, DMSO-D6) 12.4 (br s, 1H); 9.41 (br s, 2H); 8.71 (br d, 1H); 8.56 (s, 1H); 8.55 (d, 1H); 8.39 (d, 1H); 8.19 (s, 1H); 8.18 (s, 1H); 7.89 (s, 1H); 3.93 (br t, 4H); 3.87 (s, 3H); 3.25 (br m, 4H). LRMS calculated for C19H20N8 [M+H]+, 361.2; found 361.2.

Provenance & Evidence