Potassium Carbonate → HCID 178521590, compound

Participants

Reaction Steps

To a stirred solution of trans-4-({6-[1-(phenylsulfonyl)-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl)amino}cyclohexanol (0.63 g, 0.12 mmol) in MeOH (1.3 mL) was added potassium carbonate (0.051 g, (0.37 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was diluted with MeOH (10 mL) and CH2Cl2 (10 mL), silica gel was added and concentrated to a crude residue. The residue was purified by silica gel chromatography (MeOH/CH2Cl2 gradient) to afford trans-4-({6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl)amino}cyclohexanol as a yellow solid. 1H NMR (600 MHz, DMSO-D6) δ 12.95 (s, 1H); 11.99 (s, 1H); 8.75 (s, 1H); 8.53 (s, 1H); 8.19 (s, 1H); 8.14 (d, 1H); 7.92 (s, 1H); 7.64 (s, 1H); 6.79 (d, 1H); 4.49 (d, 1H); 3.79 (br s, 1H); 3.43 (br s, 1H); 1.83 (br s, 2H); 1.31 (br s, 2H); 1.26 (q, 4H). LRMS (ESI) calculated for C20H21N7O [M+H]+, 376.2; found 376.1.

Provenance & Evidence