Sodium sulfate decahydrate → HCID 57502448, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-({6-[5-[1-(2-ethoxy-2-oxoethyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}oxy)piperidine-1-carboxylate (0.10 g, 0.15 mmol) in tetrahydrofuran (2 mL) was added lithium aluminium hydride (11 mg, 0.29 mmol) (CAUTION: GAS EVOLUTION). The reaction mixture was stirred at room temperature for 2.5 h then cooled in an ice bath. Sodium sulfate decahydrate (0.32 mL, 1.5 mmol) was added to the reaction mixture slowly (CAUTION: GAS EVOLUTION). The reaction mixture was warmed to room temperature and filtered through celite. The filtrate was concentrated to a crude solid and purified by reverse phase HPLC to afford tert-butyl 4-({6-[5-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}oxy)piperidine-1-carboxylate. LRMS (ESI) calculated for C32H35N7O6S [M+H]+, 646.2; found 646.2.

Provenance & Evidence