HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1926665Generated: November 1, 2026
Thionyl Chloride → 3-Trifluoromethylbenzhydryl chloride
https://huagongshe.com/reaction/1926665
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Trifluoromethyl)benzhydrol | HCID 2777404 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Trifluoromethylbenzhydryl chloride | HCID 596829 | 90.5% |
Reaction Steps
To a solution of 3-(trifluoromethyl)benzhydrol (5 mL, 20 mmol) in CH2Cl2 (10 mL) was added dropwise thionyl chloride (3 mL, 41 mmol) at rt. The reaction was stirred at 50° C. for 18 h, concentrated under vacuum, azeotroped with toluene and dried under vacuum to give the title compound (4.9 g, 89% yield) as oil, which was used in the next step without further purification. MS (ESI, pos. ion) m/z: 235.0 (M-HCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183244B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-1e59f82beeba42949a0158c5c0e554fb |
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| Source note | uspto-grants-2012_05 |
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