HCID 49846267, compound → HCID 49846266, compound

Participants

Reaction Steps

Following the procedure for the preparation of (3R)-3-amino-7-bromo-1-hydroxy-3,4-dihydroquinolin-2(1H)-one (29) in Example 5 but using tert-butyl {(3S)-7-bromo-1-[(tert-butoxycarbonyl)oxy]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}carbamate (28) as starting material, the title product was obtained as a white powder (23 mg, 62%). LCMS m/z 258.9 (M+1). 1H NMR (500 MHz, DMSO-d6) δ 2.70 (br dd, J=15.6, 12.7 Hz, 1H) 2.99 (dd, J=15.6, 6.1 Hz, 1H), 3.52 (dd, J=12.7, 6.0 Hz, 1H), 7.16-7.20 (m, 2H), 7.28 (d, J=1.6 Hz, 1H).

Provenance & Evidence