Diethyl acetamido(4-bromo-2-nitrobenzyl)malonate → HCID 59627195, compound

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Reaction Steps

Diethyl acetamido(5-chloro-3-methyl-2-nitrobenzyl)malonate (39) Following the procedure for the preparation of diethyl acetamido(4-bromo-2-nitrobenzyl)malonate (24) in Example 5,1-(bromomethyl)-5-chloro-3-methyl-2-nitrobenzene (38) was converted to the title product, which was obtained as a solid (65%). LCMS m/z 401.0 (M+1). 1H NMR (400 MHz, DMSO-d6) δ 1.15 (t, J=7.1 Hz, 6H), 1.90 (s, 3H), 2.24 (br s, 3H), 3.53 (s, 2H), 4.10-4.17 (m, 4H), 7.05 (br d, J=2.2 Hz, 1H), 7.56 (apparent dd, J=2.3, 0.7 Hz, 1H), 8.31 (br s, 1H).

Provenance & Evidence