Potassium Carbonate → 4-(Pyrimidin-5-yloxy)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of pyrimidin-5-ol (0.384 g, 4.0 mmol) in DMF (4.0 mL) were added 4-fluorobenzaldehyde (0.429 g, 4.0 mmol), sodium methanesulphinate (0.118 g, 1.0 mmol) and potassium carbonate (0.828 g, 6.0 mmol). The reaction mixture was heated at 120° C. for 3 hours, cooled to ambient temperature, treated with water and extracted three times with TBME. The extracts were washed with brine, dried and concentrated. Column chromatography gave 0.523 g (43%) of the subtitle compound.

Provenance & Evidence