4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde → HCID 57743064, compound

HRID 1926747Notes

Reaction equation

HRID 1926747 reaction equation
CC1C(CN2CC(C3C=C(F)C=C(F)C=3F)CC2=O)=C(C)N(S(C2C=CC(C)=CC=2)(=O)=O)N=1.Cl.[NH2:35][CH2:36][CH:37]([C:44]1[CH:49]=[C:48]([F:50])[CH:47]=[C:46]([F:51])[C:45]=1[F:52])[CH2:38][C:39]([O:41]CC)=O.[Br:53][C:54]1[CH:55]=[N:56][N:57]([CH3:61])[C:58]=1[CH:59]=O>>[Br:53][C:54]1[CH:55]=[N:56][N:57]([CH3:61])[C:58]=1[CH2:59][N:35]1[CH2:36][CH:37]([C:44]2[CH:49]=[C:48]([F:50])[CH:47]=[C:46]([F:51])[C:45]=2[F:52])[CH2:38][C:39]1=[O:41]

Participants

4

Reactant 3

HCID 27946344-bromo-1-methyl-1H-pyrazole-5-carbaldehydeHCID 53629161HCID 53629161, compoundHCID 86631465HCID 86631465, compound

Product 1

HCID 57743064HCID 57743064, compound

Procedure

1-[(4-bromo-1-methyl-1H-pyrazol-5-yl)methyl]-4-(2,3,5-trifluorophenyl)pyrrolidin-2-one 182 is prepared as for compound x61 starting from ethyl 4-amino-3-(2,3,5-trifluorophenyl)butanoate hydrochloride x60 and 4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde x65.

Sources & evidence

ORD record
ord-4e185dedaa7b4d4a86c2020203a00ab6
Source dataset
uspto-grants-2012_05
Patent number
US08183241B2

Reaction notes

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