反应详情

In a 50 ml three-necked flask fitted with a magnetic stirrer and a reflux condenser under inert atmosphere, 1-(1-trityl-1H-imidazol-4-yl)propan-1-ol x88 (1.21 g, 3.3 mmol) and MnO2 (2.85 g, 33 mmol) are dissolved in 20 ml of dioxane and the mixture is brought to reflux for 1 h. The mixture is filtered on Celite and the solvent is evaporated. Purification by chromatography on silicagel (CH2Cl2/MeOH/NH4OH: 90/9/1 (v/v/v)) affords 0.96 g of pure 1-(1-trityl-1H-imidazol-4-yl)propan-1-one x89.

1. temperatureto reflux for 1 h
2. filtrationThe mixture is filtered on Celite
3. customthe solvent is evaporated
4. customPurification by chromatography on silicagel (CH2Cl2/MeOH/NH4OH: 90/9/1 (v/v/v))