HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Diethoxybutylamine → HCID 58016847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Diethoxybutylamine | HCID 80672 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine | HCID 58016815 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58016847 | HCID 58016847 | — |
Reaction Steps
Stir 600 mg (1.78 mmol) 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine, 344.7 mg (2.14 mmol) 4-aminobutyraldehyde-diethylacetal and 0.465 ml (2.67 mmol) DIEA in 5 ml DMF overnight at 80° C. After cooling, purify the mixture directly by preparative RP-HPLC (gradient acetonitrile/water). 746 mg (90.7% of theor.) of the target compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183246B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-91e889501b1649f99f15cb975206cf35 |
| Source note | uspto-grants-2012_05 |