Hydrochloric Acid → HCID 58016833, compound

Participants

Reaction Steps

Dissolve 640 mg (1.39 mmol) N-(4,4-diethoxybutyl)-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine-4-amine in 5 ml acetone and, at RT, add 1 ml 1 N hydrochloric acid. After 1 h, add the reaction mixture to water and extract three times with dichloromethane. Combine the organic phases and wash with buffer solution (pH 7) and saturated sodium chloride solution, dry over magnesium sulphate and concentrate under vacuum. Purify the raw product by chromatography on silica gel (solvent: dichloromethane/ethyl acetate 2:1). 191 mg (35.6% of theor.) of the target compound is obtained.

Provenance & Evidence