HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1926879Generated: November 1, 2026
Acrylonitrile → 5-(4-Methoxyphenyl)-6-phenyl-N-{3-[2-cyanoethoxy]propyl}furo[2,3-d]pyrimidine-4-amine
https://huagongshe.com/reaction/1926879
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}propan-1-ol | HCID 58016823 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-(4-Methoxyphenyl)-6-phenyl-N-{3-[2-cyanoethoxy]propyl}furo[2,3-d]pyrimidine-4-amine | HCID 58016879 | — |
Reaction Steps
Add 47 mg (0.89 mmol) acrylonitrile and 57 mg (0.83 mmol) sodium ethylate to 300 mg (0.80 mmol) of the compound from Stage 1. Stir the mixture overnight at 80° C. After cooling, take up the mixture in DMSO and purify directly by RP-HPLC (column: Gromsil 250 mm×30 mm, 10 μm; acetonitrile/water gradient: 0-3 min 5% acetonitrile, 3-50 min 5%→98% acetonitrile, 50-55 min 98% acetonitrile). 160 mg (47% of theor.) of the title compound is obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183246B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-8ed139b7c6bc4bf797d30a72ed8a48b3 |
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| Source note | uspto-grants-2012_05 |
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