反应详情

Put 10 g (63.2 mmol) 6-oxo-heptanoic acid methyl ester in 50 ml methanol. Add, in portions, 1.196 g (31.6 mmol) sodium borohydride. After the exothermic reaction has subsided, stir for a further 30 min under reflux. Then concentrate by evaporation. Take up the residue in water, acidify with 1 M hydrochloric acid and extract twice with dichloromethane. Dry the organic phases and concentrate by evaporation. 7.9 g (78.0% of theor.) of the target compound is obtained.

1. customAfter the exothermic reaction
2. temperatureunder reflux
3. concentrationThen concentrate by evaporation
4. extractionextract twice with dichloromethane
5. customDry the organic phases
6. concentrationconcentrate by evaporation
7. custom7.9 g (78.0% of theor.) of the target compound is obtained