HuagongsheHuagongshe Chemistry Print Report · For research reference only
R-(-)-1,2-Propanediol → (2R)-2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | R-(-)-1,2-Propanediol | HCID 259994 | — |
| Reactant | (S)-propane-1,2-diol | HCID 439846 | — |
| Reactant | 4-Chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine | HCID 58016815 | — |
| Reactant | 4-Chloro-5-(4-ethylphenyl)-6-phenylfuro[2,3-d]pyrimidine | HCID 58016897 | — |
| Product | (2R)-2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}propan-1-ol | HCID 58016907 | — |
Reaction Steps
Production of the compounds listed in the following table is analogous to the synthesis described above. It starts correspondingly from 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]-pyrimidine or from 4-chloro-5-(4-ethylphenyl)-6-phenylfuro[2,3-d]pyrimidine and uses (2S)-propane-1,2-diol or (2R)-propane-1,2-diol respectively:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183246B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d214f2471ab2466a8aa6de20bb654620 |
| Source note | uspto-grants-2012_05 |