反应详情

Dissolve 4.1 g (11.1 mmol) 6-{[5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester at room temperature in 150 ml carbon tetrachloride and add 2.2 g (12.2 mmol) N-bromosuccinimide. Stir the mixture under reflux for three hours, then filter after cooling to room temperature and concentrate the filtrate by vacuum evaporation. 4.8 g (96% of theor.) of the title compound is obtained.

1. temperatureunder reflux for three hours
2. filtrationfilter
3. concentrationconcentrate the filtrate
4. customby vacuum evaporation