6-Aminohexanoic Acid → HCID 23627862, compound

Participants

Reaction Steps

Stir 1.0 g (3.0 mmol) 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine, 0.78 g (5.94 mmol) 6-aminohexanoic acid and 1.5 ml DIEA in 10 ml DMF overnight at 120° C. Add the reaction mixture to water and extract three times with ethyl acetate. Combine the organic phases and wash with saturated sodium chloride solution, dry over magnesium sulphate and concentrate by vacuum evaporation. Chromatograph the residue on silica gel (solvent: cyclohexane/ethyl acetate 2:1→1:2). 560 mg (43.7% of theor.) of the target compound is obtained.

Provenance & Evidence