Sodium Carbonate → HCID 58016808, compound

Participants

Reaction Steps

Stir 55 mg (0.131 mmol) 6-[(6-bromo-5-phenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoic acid methyl ester, 0.131 ml of 2 M aqueous sodium carbonate solution (0.26 mmol), 4.6 mg (0.006 mmol) bis(triphenylphosphine)palladium(II) chloride and 20 mg (0.164 mmol) phenylboronic acid under argon in 0.4 ml DMSO for 1 h at 80° C. After cooling, purify the mixture directly by preparative RP-HPLC (gradient: water/acetonitrile). 35 mg (64.1% of theor.) of the target compound is obtained.

Provenance & Evidence