Hydrochloric Acid → HCID 58016928, compound

Participants

Reaction Steps

Dissolve 27.5 mg (0.066 mmol) 6-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoic acid methyl ester in 0.1 ml methanol, 0.05 ml THF and one drop of water and add 0.09 ml 2.5 M sodium hydroxide solution. Stir the mixture for 1 h at RT and then lightly acidify with 1 N hydrochloric acid. Extract the aqueous phase three times with dichloromethane. Combine the organic phases and dry over magnesium sulphate, concentrate by vacuum evaporation and dry the residue at high vacuum. 25 mg (96.1% of theor.) of the target compound is obtained.

Provenance & Evidence