Dichloromethane → HCID 58016959, compound

Participants

Reaction Steps

Add 42.8 mg sodium hydride (60% dispersion in oil, approx. 1.07 mmol) in portions, at RT, to a mixture of 300 mg (0.89 mmol) 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 214 mg (1.34 mmol) 6-hydroxyhexanoic acid ethyl ester in 1.0 ml THF and 0.7 ml DMF. Stir the mixture for 1 h at RT, and then add dichloromethane and water. Wash the organic phase with saturated sodium chloride solution, dry over sodium sulphate and concentrate by vacuum evaporation. After preparative RP-HPLC, 120.9 mg (29.5% of theor.) of the target compound is isolated from the residue.

Provenance & Evidence