Dimethyl Sulfoxide → HCID 58016967, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 200 mg (0.463 mmol) [(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)(methyl)amino]hexanoic acid methyl ester in 1.25 ml DMSO and 0.125 ml methanol. Add successively, under argon at RT, 16.2 mg (0.023 mmol) bis(triphenylphosphine)palladium(II) chloride, 127 mg (0.925 mmol) potassium carbonate and 105.4 mg (0.694 mmol) 4-methoxyphenylboronic acid. Heat the mixture to 80° C. for approx. 3 h, stirring vigorously. After cooling, purify the reaction mixture directly by preparative RP-HPLC (gradient: acetonitrile/water). 133.9 mg (63% of theor.) of the target product is obtained.

Provenance & Evidence