Iodoethane → HCID 58016889, compound

Participants

Reaction Steps

Put 29.2 mg (0.068 mmol) 6-({5-[4-aminophenyl]-6-phenylfuro[2,3-d]pyrimidin-4-yl}amino)-hexanoic acid methyl ester in 0.5 ml acetonitrile with 14 μl (0.102 mmol) triethylamine and add an excess of ethyl iodide in portions at 45° C. in closed apparatus over a period of 12 h. After cooling, dilute the reaction mixture with dichloromethane, wash successively with satd. sodium hydrogencarbonate solution and satd. sodium chloride solution, dry over sodium sulphate and concentrate by vacuum evaporation. After preparative RP-HPLC (gradient: acetonitrile/water), 6.2 mg of the target compound (19.9% of theor.) is isolated from the raw product mixture.

Provenance & Evidence