Sodium Hydroxide → HCID 25096159, compound

Participants

Reaction Steps

Put 20 mg (0.027 mmol) (+/−)-4-[(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}propyl)(methyl)amino]butanoic acid methyl ester in 0.8 ml THF. Add 0.27 ml (0.27 mmol) 1 N sodium hydroxide solution and stir overnight at RT. Then concentrate by evaporation and purify the residue by thick-layer chromatography on silica gel (solvent: dichloromethane/methanol 9:1). Extract the product zone with dichloromethane/methanol 7:3. 8.5 mg (66.3% of theor.) of the target compound is obtained.

Provenance & Evidence