HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1926949Generated: October 30, 2026
Potassium Phosphate, Tribasic → HCID 25096663, compound
https://huagongshe.com/reaction/1926949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-(2-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 23005421 | — |
| Reactant | Methyl 6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate | HCID 58016901 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 25096663 | HCID 25096663 | — |
Reaction Steps
Add 229 mg (1.08 mmol) potassium phosphate to a mixture of 220 mg (0.49 mmol) 6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester and 17 mg (0.03 mmol) bis(triphenylphosphine)palladium(II) chloride in 2.2 ml toluene. Next, add 176 mg (0.74 mmol) (2-chlorophenyl)boronic acid pinacol ester and stir the mixture for 15 h at 80° C. Purify the reaction mixture directly by preparative RP-HPLC (gradient: water/acetonitrile). 101 mg (42% of theor.) of the desired product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183246B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-d5a6426d797b497dac0f09ab2ff88c9c |
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| Source note | uspto-grants-2012_05 |
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