Hydrochloric Acid → 6-{[5-(4-Methoxyphenyl)-6-(2-methylphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid

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Reaction Steps

Dissolve 65 mg (0.14 mmol) 6-{[5-(4-methoxyphenyl)-6-(2-methylphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 2.5 ml dioxan and add 0.50 ml 1 N sodium hydroxide solution. Stir for 16 h at RT, then add 0.50 ml 1 N hydrochloric acid and then 6 ml methyl acetate. Separate the organic phase, dry over sodium sulphate, filter, and concentrate by evaporation. 53 mg (82% of theor.) of the target compound is obtained.

Provenance & Evidence