HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58016826, compound → HCID 58016765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58016826 | HCID 58016826 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58016765 | HCID 58016765 | — |
Reaction Steps
Dissolve 70 mg (0.14 mmol) rac.-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}-2-methylpropoxy)acetic acid tert.-butyl ester in 2.0 ml 4 N hydrogen chloride in dioxan and stir for 16 h at RT. Purify directly by preparative RP-HPLC (gradient: water/acetonitrile). 48 mg (76% of theor.) of the desired product is obtained as racemate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183246B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f9d4d668f6e440cc8f8c296d81a65985 |
| Source note | uspto-grants-2012_05 |