Hydrochloric Acid → HCID 58016765, compound

Participants

Reaction Steps

Dissolve 45 mg (0.09 mmol) (3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}-2-methylpropoxy)acetic acid tert.-butyl ester (Enantiomer 2) in 0.5 ml dioxan, add 0.2 ml 4 N hydrogen chloride in dioxan and stir for 48 h at RT. Then add a further 0.4 ml 4 N hydrogen chloride in dioxan to the reaction mixture and stir again for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 21 mg (53% of theor.) of the desired product is obtained as Enantiomer 2.

Provenance & Evidence