4-{[(2S)-2-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}propyl]-(methyl)amino}butyric acid tert.-butyl ester → (+)-4-{[(2S)-2-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}propyl]-(methyl)amino}butyric acid

Participants

Reaction Steps

Dissolve 102 mg (93% purity, 0.19 mmol) 4-{[(2S)-2-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}propyl](methyl)amino}butyric acid tert.-butyl ester in 2 ml 4 N hydrogen chloride in dioxan and stir for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 48 mg (52% of theor.) of the desired product is obtained.

Provenance & Evidence