((R)-3-amino-2-hydroxy-propyl)-cyclohexylmethyl-phosphinic acid benzyl ester hydrochloride → HCID 178448354, compound

Participants

Reaction Steps

The title compound was prepared substantially following the procedures as set forth in Method B, Example 12, and employing ((R)-3-amino-2-hydroxy-propyl)-cyclohexylmethyl-phosphinic acid benzyl ester hydrochloride and N-Cbz-His-Val-OH as the starting materials, which yielded the title compound as a white powder. 1H NMR (CD3OD, 300 MHz): δ 8.47 (s, 1H), 7.25 (s, 1H), 4.25 (t, 1H), 4.10 (d, 1H), 4.0 (m, 1H), 3.6-3.5 (dd, 1H), 3.10-3.00 (m, 2H), 2.09-2.02 (m, 1H), 1.95-1.86 (m, 2H), 1.80-1.54 (m, 8H), 1.41-1.02 (m, 3H), 1.0-0.95 (m, 9H). 31P NMR (CD3OD, 300 MHz): δ 42.66. LCMS m/z: [M+H]+=472.

Provenance & Evidence