Hydrazine → HCID 59262506, compound

HRID 1927173Notes

Reaction equation

HRID 1927173 reaction equation
C([O:3][C:4](=O)[C:5]([S:8](=[O:17])(=[O:16])[NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)([CH3:7])[CH3:6])C.[NH2:19][NH2:20]>C(O)C>[CH:10]1([NH:9][S:8]([C:5]([C:4]([NH:19][NH2:20])=[O:3])([CH3:7])[CH3:6])(=[O:17])=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 129373992-Cyclohexylsulfamoyl-2-methylpropionic acid ethyl ester

Product 1

HCID 59262506HCID 59262506, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using a method similar to that described by S. Paik and E. H. White (Tetrahedron, 1996, 52, 5303), 2-cyclohexylsulfamoyl-2-methylpropionic acid ethyl ester DF1 (which is prepared by the method of A. De Blic et al. (Synthesis, 1982, 281)) in ethanol is treated with 1.2 equivalent of 95% hydrazine under N2 and the mixture is allowed to stand at RT for 12 h. The reaction mixture is concentrated to give the title compound DF2 which is used directly in Step 2.

Workup

  1. concentrationThe reaction mixture is concentrated

Sources & evidence

ORD record
ord-2b935bd805be434187cf2aa15f5a385a
Source dataset
uspto-grants-2012_05
Patent number
US08183252B2

Reaction notes

Loading…