HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl propiolate → CGP-47292 methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl propiolate | HCID 13536 | — |
| Reactant | 2-(Azidomethyl)-1,3-difluorobenzene | HCID 10888323 | — |
| Product | CGP-47292 methyl ester | HCID 22716778 | — |
Reaction Steps
The process may involve reacting 2-(azidomethyl)-1,3-difluorobenzene of formula III with methyl propiolate, to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV, and converting the methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV to rufinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183269B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a4956d862f6b4a598a914dd96a374cbb |
| Source note | uspto-grants-2012_05 |