Tetrahydrofuran → 5-(2-(Trimethylsilyl)ethynyl)pyridin-2-amine

Participants

Reaction Conditions

Reaction Steps

To a solution of THF (10 mL) and water (5 mL) of 2-nitro-5-trimethylsilanylethynyl-pyridine (410 mg) described in Manufacturing Example 3-1 were added iron powder (510 mg) and ammonium chloride (200 mg) at room temperature, which was stirred for 75 minutes at 70° C. The reaction solution was cooled to room temperature, and then filtered through Celite, and the solvent was evaporated from the filtrate under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1) to obtain the titled compound (320 mg).

Provenance & Evidence