Sodium Azide → HCID 24882976, compound

Participants

Reaction Steps

To a solution of NMP (200 μL) and water (200 μL) of 3-ethynyl-pyridin-2,6-diamine (20 mg) described in Manufacturing Example 4-3 were added 1-benzyloxy-4-chloromethyl-benzene (37 mg), sodium azide (15 mg), copper sulfate (4.8 mg), and copper (7.4 mg) at room temperature, and this mixture was irradiated for 30 seconds at no higher than 125° C. with 100 W microwaves. Aqueous sodium bicarbonate was added to the reaction mixture, which was extracted with ethyl acetate. The solvent was evaporated from the organic layer under a reduced pressure. The residue was purified by NH silica gel column chromatography (heptane:ethyl acetate=1:3, then with ethyl acetate) to obtain the titled compound (1.2 mg).

Provenance & Evidence