HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 3-(2H-Tetrazol-5-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-Amino-3-cyanopyridine | HCID 818259 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 3-(2H-Tetrazol-5-yl)pyridin-2-amine | HCID 13101657 | 97% |
Reaction Steps
2-Amino-3-cyanopyridine (1.0 g), sodium azide (1.1 g), ammonium chloride (0.89 g), and DMF (15 mL) were stirred for 1.5 hours at 100° C. The reaction solution was directly purified by silica gel chromatography (ethyl acetate, then ethyl acetate:methanol:concentrated aqueous ammonia=6:2:0.5) to obtain the titled compound (0.66 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183264B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8b6edd4ad69248b780c40b246768fcaf |
| Source note | uspto-grants-2012_05 |