Sodium Hydroxide → HCID 59287378, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-6-methoxymethyl-nicotinamide (90 mg) described in Manufacturing Example 6-1 and phosphorus oxychloride (3.0 g) were stirred for 0.5 hour at 100° C. The reaction solution was added to 0° C. dilute aqueous sodium hydroxide and then extracted with ethyl acetate. The organic layer was concentrated and the residue was purified with silica gel chromatography (ethyl acetate) to obtain the titled compound (40 mg).

Provenance & Evidence