Triethylamine hydrochloride → HCID 59287388, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Diamino-nicotinonitrile (0.50 g) described in Manufacturing Example 7-2, sodium azide (1.2 g), triethylamine hydrochloride (5.1 g), and NMP (45 mL) were stirred for 11 hours at 160° C. The reaction solution was directly purified by silica gel chromatography (ethyl acetate, then ethyl acetate:methanol:concentrated aqueous ammonia=6:2:1). The organic layer thus obtained was concentrated and purified by silica gel chromatography (ethyl acetate, then ethyl acetate:methanol=4:1, then ethyl acetate:methanol:concentrated aqueous ammonia=6:2:1) to obtain the titled compound (270 mg).

Provenance & Evidence