1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2,6-Diamino-nicotinic acid N'-(2-(4-benzyloxy-phenyl)-acetyl)-hydrazide

Participants

Reaction Steps

To a solution of DMF (1 mL) of (4-benzyloxy-phenyl)-acetic acid hydrazide (46 mg) described in Manufacturing Example 8-1 were added triethylamine (0.10 mL), 2,6-diamino-nicotinic acid (30 mg) described in Manufacturing Example 10-2-4, HOBt (27 mg), and WSC (41 mg), which was stirred overnight at the same temperature. Water was added to the reaction solution, and the precipitated solids were filtered off to obtain the titled compound (47 mg) as a crude form. This compound was used directly as a crude form in the subsequent reaction.

Provenance & Evidence