Sulfuric Acid → Methyl 2-amino-6-chloronicotinate

Participants

Reaction Conditions

Reaction Steps

To methanol (50 mL) were added concentrated sulfuric acid (25 mL) and 2-amino-6-chloro-nicotinic acid (4.3 g) described in Manufacturing Example 11-1 under ice cooling, which was stirred for 5 hours at 70° C. The reaction mixture was cooled to room temperature and then neutralized by adding an aqueous solution of sodium hydrogencarbonate (90 g) at the same temperature. The solids thus produced were filtered off to obtain the titled compound (3.2 g).

Provenance & Evidence