Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Benzyloxybenzyl chloride | HCID 70042 | — |
| Reactant | HCID 178508378 | HCID 178508378 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 24883026 | HCID 24883026 | 60.9% |
Reaction Steps
3-(1H-[1,2,4]triazol-3-yl)-pyridin-2-ylamine (20 mg) described in Manufacturing Example 14-3, 4-benzyloxybenzyl chloride (32 mg), potassium carbonate (86 mg, and DMF (3.0 mL) were stirred for 0.5 hour at 60° C. Water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was concentrated and purified by NH silica gel column chromatography (heptane:ethyl acetate=2:1, then 1:1) to obtain the titled compound (27 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08183264B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-695a234e5d3c4c4fbbffcfdd7ab41514 |
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| Source note | uspto-grants-2012_05 |
|---|
