Ammonia → (2-Amino-6-methoxymethyl-pyridin-3-yl)methanol

Participants

Reaction Steps

To a mixture of LAH (80%, 220 mg) and THF (5 mL) was added 2-amino-6-methoxymethyl-nicotinic acid methyl ester (300 mg) described in Manufacturing Example 11-3 at 0° C., which was stirred for 20 minutes at the same temperature. A 28% aqueous ammonia solution was added dropwise to the reaction mixture at the same temperature until the LAH was inactivated. The reaction mixture was warmed to room temperature and filtered. The filtrate was evaporated under a reduced pressure to obtain the titled compound (260 mg).

Provenance & Evidence