反应详情

To a mixture of (2-amino-6-methoxymethyl-pyridin-3-yl)methanol (260 mg) described in Manufacturing Example 19-1 and dichloromethane (15 mL) was added manganese dioxide (1.3 g), which was stirred overnight at room temperature. The reaction mixture was filtered through Celite, and the filtrate was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=3:2) to obtain the titled compound (210 mg).

1. filtrationThe reaction mixture was filtered through Celite
2. customthe filtrate was evaporated under a reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:heptane=3:2)