2-Fluoropyridine → (4-(Pyridin-2-yloxymethyl)-phenyl)-methanol

Participants

Reaction Conditions

Reaction Steps

To a solution of 1,4-benzenedimethanol (5.5 g) and DMF (15 mL) of 2-fluoropyridine (1.3 g) was added NaH (1.4 g/66% in oil) at 0° C., which was stirred for 1 hour at 70° C. The reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate:heptane=1:1) to obtain the titled compound (1.9 g).

Provenance & Evidence