Carbon Tetrachloride → 2-(4-Chloromethyl-benzyloxy)-pyridine

Participants

Reaction Steps

(4-(Pyridin-2-yloxymethyl)-phenyl)methanol (540 mg, 2.51 mmol) described in Manufacturing Example 26-1, triphenylphosphine (856 mg, 3.27 mmol), and carbon tetrachloride (10.8 g, 10.2 mmol) were stirred for 2 hours and 10 minutes under heating and reflux. The reaction solution was cooled to room temperature, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=8:1) to obtain the titled compound (300 mg).

Provenance & Evidence