Carbon Tetrachloride → 1-(Chloromethyl)-4-phenoxybenzene

Participants

Reaction Steps

To a solution of carbon tetrachloride (8.2 mL) of (4-phenoxy-phenyl)-methanol (410 mg) was added triphenylphosphine (640 mg) at room temperature, which was heated to reflux for 7 hours and 40 minutes under a nitrogen atmosphere. The reaction mixture was cooled to room temperature and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the titled compound (410 mg).

Provenance & Evidence