Carbon Tetrachloride → 5-(Benzyloxy)-2-(chloromethyl)pyridine

Participants

Reaction Steps

To a solution of carbon tetrachloride (10 mL) of a known compound (5-benzyloxy-pyridin-2-yl)-methanol (500 mg) was added triphenylphosphine (791 mg) at room temperature, which was heated to reflux for 19 hours and 35 minutes under a nitrogen atmosphere. The reaction mixture was cooled to room temperature, after which the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=3:1) to obtain the titled compound (386 mg).

Provenance & Evidence